His PSA was 7.4, Gleason score 10. The cancer had spread to his spine, a rib and seminal pouches. After a few hormone injections his PSA dropped to 1.1. In October he started having problems passing urine again and his PSA had started to rise again. The oncologist arranged a course of radiotherapy to start 1st of December 14 but bat the end of This is because males with elevated PSA levels may not have prostate cancer. It is best to discuss the risks and benefits of prostate cancer screening and the various testing options with a doctor. According to a 2015 review in the journal Medicine, testosterone replacement therapy also doesn’t increase prostate specific antigen (PSA) levels. PSA is a protein that’s elevated in the Official answer. by Drugs.com. Some medications can increase levels of prostate-specific antigen (PSA) in the blood, falsely indicating the presence of prostate cancer. Medications that may raise PSA levels include: Betamethasone, a steroid prescribed to reduce inflammation. Testosterone replacement therapy, including Jatenzo, a testosterone It’s anxiety provoking to have to wait for one or more repeat blood tests to find out if PSA is coming back down. Thankfully, a presentation by Monaco, et al. [iii] at the 2022 annual meeting of the American Urological Association offers some real clues—not red herrings—to help tell whether a rising PSA is more likely a bounce than The PSA level is the most valuable tool for monitoring disease status and the treatment response, especially in patients with advanced metastatic prostate cancer, as shown in many studies [1,4,5]. However, the progression of prostate cancer can sometimes occur in the presence of an undetectable or low serum PSA level. I suspect the very low levels you see now are either due to a very small amount of normal prostate tissue left after surgery or other tissues making PSA. Levels below 0.1 ng/mL are of uncertain When PSA returned to normal values (<4 ng/mL) both risks of prostate cancer and high-grade disease were reduced (OR 0.33 and 0.01, respectively, P = 0.001). Conclusion: In a cohort of Italian men undergoing prostate biopsy, a reduction of ≥20% in PSA levels significantly reduced the risk of high-grade prostate cancer. Further multicentre hxBaq3.